Ressource Scientifique

Challenges and perspectives in the preclinical development of therapeutic agents against lung fibrosis
In this blog, Pauline Bornert examines the current knowledge about pulmonary fibrosis, and preclinical options available to develop new therapeutic solutions.

Preclinical evaluation of a chimpanzee adenovirus vector expressing a pre-fusion Spike (BV-AdCoV-1) SARS-CoV-2 intranasal vaccine candidate in golden Syrian hamsters
Download the e-poster and learn more about Chimpanzee Adenovirus vector SARS-CoV-2 intranasal Vaccine Candidate from Oncodesign Services.

New target identification and validation platform combining AI in oncology and preclinical pharmacology
The OncoSNIPE® project combines Ai in Oncology and Preclinical Pharmacology to develop a new identification and validation platform. Learn more here

DRIVE-Biologics: all the steps from discovery to development of novel biological therapeutics
DRIVE-Biologics aims to optimize your biologics therapeutics and drug discovery through stages of preclinical evaluation to clinical studies. Learn more here

Simultaneous 18F-FDG PET / MR imaging for metastases identification in a disseminated human preclinical melanoma model
Simultaneous 18F-FDG PET / MR imaging for metastases identification in a disseminated human preclinical Melanoma Model. Learn more here

OncoTAM, a comprehensive preclinical platform to explore macrophages
OncoTAM targets Tumor Associated Macrophages to develop new Anticancer Therapies in a form of a comprehensive preclinical platform. Learn more here

Antitumor activity comparison of two somatostatin receptor ligands radiolabeled with Lutetium-177 (SSO110 and DOTA-TATE)
Somatostatin Receptor ligands Antitumor Activity comparison radiolabeled with Lutetium 177 alone or combined with chemotherapy in mice. Learn more here

Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases
New study investigates Pharmacological Inhibitors of DYRK and CLK Protein Kinases and their comparative efficacy and selectivity. Learn more here

A Rhenium(I)-Diselenoether Compound Significantly Decreased the Viral Load of SARS-CoV-2 in Infected Pulmonary Cells
Rhenium(I) tricarbonyl complexes inhibited the 3- chymotrypsin-like protease (3CLpro) which is one of the main proteases of the severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2 virus), but the antiviral effect was not studied.

IBD Case study
Discover an example of a screening cascade developed by Oncodesign Services that led to the identification of preclinical candidates.

Why do preclinical cancer models still fail in the clinic?
We at Oncodesign Services strive to develop alternative Preclinical Cancer Models to better suit your drug development. Read more about our solutions here.

Liposomal Irinotecan Shows a Larger Therapeutic Index than Non-liposomal Irinotecan in Patient-Derived Xenograft Models of Pancreatic Cancer
Liposomal Irinotecan is hypothesized to have a higher therapeutic index than its non-liposomal counterpart in mice with Pancreatic Cancer. Read more here.