Download Digital CDX Guide
Cell line-derived xenograft (CDX) models enable in vivo efficacy testing in an environment that better simulates the human immune system, allowing researchers to more accurately assess how a new therapy is likely to perform in humans.
CDX models are developed by implanting cultured cancer cell lines into immunodeficient mice to promote tumor growth, against which candidate therapies can be tested. A strategically selected panel of research models enables evaluation of treatment efficacy in a more translational microenvironment before advancing a new therapeutic to clinical trials.
- CDX models are commonly used to study:
- Tumor biology, metastasis, and drug response
- Biomarker validation
- Drug resistance
- Combination therapies
CDX models are highly reproducible, fast to develop, and well-suited for high-throughput studies. We offer more than 200 unique CDX models across 17 indications, fully integrated with our in vitro experimental platform. Our models are characterized by histopathology, conserved phenotype and genotype, stable gene expression, mutation profiling, and response to standard of care (SOC). Each model can be available in humanized mouse formats, bioluminescent variants, and implanted in non-conventional anatomical sites.
If the appropriate model is not available, our experienced team can develop a customized model to match your research needs.
