Kidney models

Preclinical CRO Services

for Inflammation of the Kidney

 

Acute and chronic inflammatory diseases of the kidney can be triggered by several causes of tissue injury such as exposure to toxins, auto-immune conditions or infections. Rodent models of kidney inflammation and injury are helpful to decipher disease triggering or sustaining mechanisms observed in patients.

Oncodesign Services offers CRO services for several preclinical models addressing a variety of kidney diseases, and provides CRO support to the de novo development of new kidney inflammation models recently described in literature.

 

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Typical readouts for kidney inflammation models

  • Clinical scoring
  • Body weight
  • Histopathology
  • Biomarker/drug monitoring
  • Gene expression in kidneys, by qPCR/dPCR

Kidney Inflammation Models List

Oncodesign Services offers kidney models as :

  • Acute kidney injury model in mice, induced by Cisplatin
  • Diabetic nephropathy model in BTBRob/ob mice
  • Kidney fibrosis model in rats, induced by unilateral ureteral obstruction

Case study

Cisplatin-induced acute kidney injury

While cisplatin induces toxicity on various systems, including gastrotoxicity, myelosuppression, ototoxicity and allergic reactions, the major dose-limiting side effect is nephrotoxicity.

It is estimated that 20% of patients receiving high-dose cisplatin develop severe renal dysfunction and approximately one third of patients experience kidney injury just days following the first treatment.

Typically, serum creatinine and urea rise within 3 days of cisplatin treatment.  Necrostatin (RIPK-1 inhibitor) alleviates kidney dysfunction induced by cisplatin.

Kidney - Cisplatin kidney injury model necrosis histology.png
Kidney - Cisplatin kidney injury mouse model necrostatin response