Autoimmunity models

Preclinical CRO Services

for the Study of Autoimmune Diseases

 

Autoimmune diseases are triggered by dysregulated activation of immune cells, which can be linked to genetic causes. Rodent models of autoimmunity are helpful to decipher the disease triggering or sustaining mechanisms observed in patients.

Oncodesign Services offers CRO services for several preclinical models addressing a variety of autoimmune pathologies, and provides support for the de novo development of new autoimmune  models recently described in literature.

 

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Typical Autoimmunity Readouts

  • Clinical scoring
  • Body weight
  • Histopathology
  • Biomarker/drug monitoring
  • Gene expression in relevant tissues, by qPCR/dPCR

 

Autoimmunity Models

Industry-standard models are offered as well as new model development services:

  • Collagen-induced arthritis in mice
  • Collagen-induced arthritis in rats
  • Type-1 diabetes (T1D) in NOD mice
  • Type-2 diabetes (T2D) in genetically obese leptin receptor-deficient mice
  • Acute experimental autoimmune encephalomyelitis (EAE) / Multiple sclerosis (MS) model in mice, MOG35-55 peptide induced
  • Remitting-relapsing experimental autoimmune encephalomyelitis (EAE) / Multiple sclerosis (MS) model in mice ,.PLP139-151 peptide induced

Case Study

Rheumatoid arthritis preclinical rat model

Collagen-induced arthritis in rats is a model of chronic inflammatory synovitis that resembles human RA.  Genetically susceptible Lewis rats immunized intra-dermally with type II collagen emulsified in Freund’s incomplete adjuvant (prime & boost, 1 week apart) develop a polyarthritis within 10-14 days.

Autoimmunity - Collagen-induced arthritis score in rat
Autoimmunity-BodyWeightRatio collagen-induced arthritis in rat