SOLO-DMPKS-BIOANALYSIS | Oncodesign

Bioanalysis, Formulation, Immunogenicity and Biomarkers

High-value bioanalytical services to move your compound from discovery to the clinic

Oncodesign Services offers formulation, immunogenicity and bioanalytical sample analysis services including platforms for small molecules (NCEs), peptides, large molecules (NBEs), monoclonal antibodies (mAb), Antibody-Drug Conjugates (ADC), Anti Drug Antibodies (ADA), Neutralizing Antibodies (Nab), oligonucleotides (OGN) and biomarkers (simplex/multiplex).

We are experienced with a broad range of biological matrices in both animal species and humans (serum, plasma, blood, urine, feces, animal tissues, CSF, vitreous humor, tears, saliva and human tissues).

Our experience will allow us to quickly judge whether the feasibility of the bioanalytical method is reachable.

With a large panel of equipment, we offer method development/transfer, method validation and sample analysis at research grade and GLP / GcLP-compliant for quantification by LC- MS/MS, Ligand Binding Assays (LBA), (RT)-PCR and Flow Cytometry (FACS).

Fit-for-Purpose Bioanalysis is a key element of the integrated offer DRIVE-SM  as it speed up the Design-Make-Test-Analyze (DMTA) cycle in vitro/vivo DMPK assays for small molecules and Regulatory (GLP/GcLP grade) Bioanalysis for all new therapeutic entities needs to be planned ahead prior to IND-enabling packages.

ODS offers a large panel of bioanalytical technologies under the same roof and 20 years of expertise in bioanalysis to match your needs in terms of speed, sensitivity and throughput.

  • LC-UV, LC-MS/MS and LC-HRMS

    LC-UV system (GLP-grade formulation)

    • Shimadzu Nexera X2 UHPLC system with UV and fluorescence detection dedicated for GLP-compliant formulation (In vitro GLP assays such mammalian cell micronucleus assay, Ames assay, chromosome abberation assay, hERG assay, etc… and In vivo GLP TK studies)

     

    UHPLC-MS/MS systems (Non GLP and GLP-grade bioanalysis)

    • Sciex API4000
    • Sciex API4000 QTRAP
    • Sciex API4500
    • Sciex API5000
    • Sciex API5500
    • Sciex API6500 QTRAP

     

    LC-HRMS

    • Thermo Orbitrap LTQ XL
  • FACS

    Two cytometers with 96-well plate reader system and 4 to 6 lasers on board (Becton Dickinson Fortessa X20 and Beckman coulter Cytoflex LX)

    FACS - Two cytometers with 96-well plate reader system

  • PCR (Non GLP and GLP-grade bioanalysis)
    • ThermoFisher QuantStudio 7 Flex Real-Time PCR System (qPCR)
    • Qiagen QIAcuity Four digital PCR (dPCR)
  • LBA and Immunogenicity (Non GLP and GLP-grade bioanalysis)
    • BioTek™ Epoch Microplate Spectrophotometer
    • Thermo Scientific™ Multiskan Go Microplate Spectrophotometer
    • PerkinElmer EnVision® 2100 Multilabel Plate Reader
    • Luminex® xMAP™ Technology
    • MesoScale Discovery (MSD) Sector Imager QuickPlex SQ120