Discovery Services

Supplying Integrated Drug Discovery CRO services

to support your R&D programs

The challenges of modern drug discovery rely on increasing throughput, minimizing timelines from bench to bedside while having a differential proposition of treatment for patient and therefore innovative science. Oncodesign Services offers a full spectrum of drug discovery services for small molecule (New Chemical Entities, NCEs), theranostics and new biological entities, either as stand-alone (SOLO) projects or as part of integrated discovery (DRIVE) and development (INPACT) programs.

Our multi-disciplinary teams aim to deliver fast cycle times, with tight communication and determination to deliver success. We work at premier pharmaceuticals standards delivering results and processes that can be scaled-up for preclinical candidate selection and beyond. Oncodesign Services leads a consortium of partners called the DRIVE-IDDS (DRug Integrative discoVEry- Integrated Drug Discovery Service) network to bring a complete hit-finding, hit-to-lead, lead optimization to IND solution, for those needing utmost speed in their R&D programs for  small molecule, theranostics and biologics.

Working with Oncodesign Services:

  • Access to broad range of discovery capabilities
  • Access to the latest innovative technologies
  • A package deal without micromanagement burden
  • Fast cycle times
  • Creative business model structure
  • Minimal shipment burden

Integration of DMPK and Bioanalysis to the Discovery Cycle

To ensure maximum speed in the Design-Make-Test-Analyze (DMTA) cycle for small molecules, Oncodesign Services incorporates in vitro ADME assays and in vivo DMPK studies within the process cycle. We offer standard pharmacokinetics studies in mice, rats and NHP. Read more about the DMPK platform and its step-wise application to the discovery cycle.

Oncodesign Services is well-equipped to offer biodistribution studies, with a multi-modal imaging platform. Biodistribution are offered with radiolabeled compound or with compound tagged with an optical agent like luciferase. The bioanalytical platforms are also under the same roof, with 15-20 years of expertise . Bioanalytical services are offered at Discovery-grade, Good Laboratory Practice GLP and Good Clinical Laboratory Practice GcLP. We craft bioanalysis strategies to match your needs in terms of speed, sensitivity and throughput.

Read more details about our bioanalytical platforms to serve small molecules, biologics and oligonucleotide therapies, here.

Discovery - DMTA Chemistry Approach

From in vitro to in vivo proof of concept

In vitro biology is used for secondary screening of activity, using cell-imaging or flow/FACS approaches. Such assays are routinely part of the late discovery process, and supply vital Proof of Concept (PoC) about target engagement. Tumor cells, PBMCs and other human cell sources are commonly used.

In vivo pharmacology is one of Oncodesign Services’ core strengths. We offer preclinical pharmacology services from all three of our locations. Browse our models and services offerings in preclinical oncology, inflammation and infectious diseases. Well-coordinated teams keep your program moving quickly from discovery to preclinical.

De-risking packages include standard non-GLP exploratory tox in mice and rats, immunogenicity (for biologics) and the study of effects on the human microbiome.

Browse our drug discovery capabilities

1

Medicinal Chemistry

Medicinal Chemistry

Oncodesign Services offers hit finding, hit-to-lead, lead optimization and preclinical development for your research programs.

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2

Bioanalysis

Bioanalysis

Oncodesign Services offers formulation, immunogenicity and bioanalytical sample analysis services including platforms for small molecules (NCEs), peptides, large molecules (NBEs), monoclonal antibodies (mAb), Antibody-Drug Conjugates (ADC), Anti-Drug Antibodies (ADA), Neutralizing Antibodies (Nab), oligonucleotides (OGN) and biomarkers (simplex/multiplex).

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3

In vitro biology

In vitro biology

Oncodesign Services offers both off-the-shell assays using commercial kits and in-house developed assays with customized reagent panels.

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4

Pharmaco-Imaging

Pharmaco-Imaging

Discover Oncodesign Services’ in vivo multi-modal imaging platform for non-invasive studies to support proof of concept in pharmacology.

READ MORE

 

5

DMPK

DMPK

Oncodesign Services studies the pharmacokinetics and metabolism of your new therapeutic entities.

READ MORE

 

6

In vivo pharmacology

In vivo pharmacology

From its inception, Oncodesign Services has dedicated efforts to centralize skills, assays and expertise to conduct complete preclinical pharmacological characterization of drugs in the field of oncology, immunology, immune-inflammation or infectious diseases. Our multi-disciplinary team keeps your program moving quickly by providing proof of concept for your lead compounds.

READ MORE

Medicinal Chemistry

Oncodesign Services offers hit finding, hit-to-lead, lead optimization and preclinical development for your research programs.

READ MORE

 

Bioanalysis

Oncodesign Services offers formulation, immunogenicity and bioanalytical sample analysis services including platforms for small molecules (NCEs), peptides, large molecules (NBEs), monoclonal antibodies (mAb), Antibody-Drug Conjugates (ADC), Anti-Drug Antibodies (ADA), Neutralizing Antibodies (Nab), oligonucleotides (OGN) and biomarkers (simplex/multiplex).

READ MORE

In vitro biology

Oncodesign Services offers both off-the-shell assays using commercial kits and in-house developed assays with customized reagent panels.

READ MORE

Pharmaco-Imaging

Discover Oncodesign Services’ in vivo multi-modal imaging platform for non-invasive studies to support proof of concept in pharmacology.

READ MORE

 

DMPK

Oncodesign Services studies the pharmacokinetics and metabolism of your new therapeutic entities.

READ MORE

 

In vivo pharmacology

From its inception, Oncodesign Services has dedicated efforts to centralize skills, assays and expertise to conduct complete preclinical pharmacological characterization of drugs in the field of oncology, immunology, immune-inflammation or infectious diseases. Our multi-disciplinary team keeps your program moving quickly by providing proof of concept for your lead compounds.

READ MORE