Pharmaco-Imaging

Pharmaco-imaging, a non-invasive approach to support proof of concept in pharmacology

Oncodesign Services has added pharmaco-imaging to its pharmacology platform in 2004, integrating along the years multimodalities:

• MRI 4.7T
• Nuclear imaging (PET/CT, SPECT/CT, PET/MR)
• Optical imaging (Bioluminescence, Fluorescence)
• Ultrasound

Oncodesign Services’ in vivo multi-modal imaging platform can be used for biodistribution studies, tumor tracking and to detect biomarkers of activity. Pharmaco-imaging studies often work with radioisotopes, leveraging the capabilities of our bioconjugation and radiochemistry capabilities. It is applicable to small molecules, biologics, nanoparticles.

Pharmimage® – a non-invasive pharmaco-imaging capability

Our technology module, Pharmimage® is designed to monitor the effect of treatments and to define effective translational biomarkers in precision medicine. It helps to answer questions using non–invasive, whole–body techniques:

• Is the target expressed? (Diagnosis of the disease, heterogeneity of target expression, distribution of the target in metastatic cancer, CNS, cardiology, etc.)
• Does the drug reach the target? (Pharmacokinetics, biodistribution, blood–brain barrier crossing, etc.)
• Is the target inhibited/activated, and does this induce biochemical and biological changes? (Pharmacodynamics, immunomonitoring, optimal biological dose, etc.)
• Are there any potential toxicities and drug interactions? (Safety, study on drug combinations, metabolism, etc.)
• Are these changes related to a clinical criterion? (Efficacy of a new treatment, monitoring of the immune response to a vaccine, emergence of resistance in precision medicine, etc.)
• Can subpopulations of responders be determined? (Translational biomarker)