AACR Annual Meeting 2023

Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases

IBD Case study

Discover an example of a screening cascade developed by Oncodesign Services that led to the identification of preclinical candidates.

Congress in March’23

Oncodesign is taking part in many events this fall. Here is a short selection of where we are travelling over the next few weeks.

The International Day of Women and Girls in Science

11th February has been proclaimed the ‘International Day of Women and Girls in Science’. For this occasion, we met with four women employees of Oncodesign Services...

Why preclinical cancer models still fails in the clinic?

Why 95% of compounds tested in clinical trials will never become a medicine? Yet in the discovery lab and preclinical work, all will have looked promising...

Oncodesign S.A. is now Oncodesign Services S.A.

Liposomal Irinotecan Shows a Larger Therapeutic Index than Non-liposomal Irinotecan in Patient-Derived Xenograft Models of Pancreatic Cancer

Liposomal irinotecan promotes controlled sustained release of irinotecan (CPT-11), therefore, we hypothesize that the therapeutic index (quantitative measurement of the relative efficacy/safety ratio of a drug) will be higher for liposomal than non-liposomal irinotecan.

Oncodesign Services looks to the future

Calcium(II)-Catalyzed Chemoselective and Regioselective Epoxide Ring-Opening with NH Sulfoximines

We describe herein a versatile methodology for the synthesis of 1,2-sulfoximidoyl ethanols thanks to a Ca(NTf2)2-catalyzed epoxide ring-opening with NH sulfoximines in 2-MeTHF at 90 °C.

Why studying the gut microbes could help to cure?

The human intestine hosts diverse microbial communities, with bacteria as most numerous members, that play a significant role in maintaining health and homeostasis throughout the body.  But how gut microbes talk to different organs?  

Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

We evaluated the immunogenicity and protective ability of a chimpanzeereplication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in goldenSyrian hamsters.