Liver models

Preclinical CRO Services

for Inflammatory Diseases of the Liver

 

Acute and chronic inflammatory diseases of the liver tract can be triggered by several causes such as exposure to toxic chemicals, diet or immune dysregulation. Rodent models of liver inflammation are helpful to decipher the disease triggering or sustaining mechanisms observed in patients.

Oncodesign Services offers CRO services for several preclinical models addressing a variety of liver diseases, and provides CRO support for de novo development of new research models recently described in literature.

GET IN TOUCH

Typical readouts in liver inflammation

  • Steatosis
  • Fibrosis
  • NASH score
  • Neutrophil infiltration
  • Serum markers of liver injury: LDH, ALT, AST
  • Inflammation markers
  • Immune cell infiltrates
  • Ballooning degeneration of hepatocytes
  • Apoptosis markers or necrotic histology
  • Gene expression in liver, by qPCR/dPCR
  • Biomarker / drug monitoring

Discover Oncodesign Services offers for liver inflammation diseases

Integrated Drug Discovery Services by Oncodesign

Case studies in liver inflammation

The CCl4 model of liver fibrosis is a classic model widely used in industry.  Juvenile mice are given repeated doses of CCl4.Liver fibrosis then typically appears at 6 weeks old.

This model is useful for therapies aiming to modulate collagen depositions and expression of metalloproteases.  ALK5 (TGFb receptor I) inhibition, a well-known anti-fibrotic mechanism, decreases collagen induction and is used as a reference compound.

 

Liver - CCl4 liver fibrosis biomarker results
Liver - CCl4 liver fibrosis model gene expression ALK5 inhibitor response