Cell Line-Derived Xenograft (CDX) models for in vivo pharmacology studies
Cell Line-Derived Tumors Xenograft models (CDX) are developed for the research and testing of new therapies against cancer. In translational research, human tumor samples are cultured as cell lines and implanted into immunodeficient mouse. The objective is to evaluate the efficacy of new compounds in vivo.
CDX models give you quality data and predictive information of how the new therapy will perform, before entering into clinical trials.
Oncodesign Services has a large bank of characterized CDX models
At Oncodesign Services, our customers have access to a comprehensive collection of CDX models on mouse or rat, covering 17 organ origins (liver, breast, lung, brain, pancreas, …)
Our CDX mouse models are fully integrated with our in vitro experimental platform dedicated to preclinical pharmacology.
Example of popular human CDX models:
| Breast | BT-474 | MDA-MB-231 | MX-1 | MDA-MB-468 | MCF-7 |
| Brain | U87MG |
| Blood | MV4.11 | Raji | Ramos | K-562 | Karpas-299 |
| Colon | HCT-116 | Ls174T | COLO-205 | HT-29 | LoVo |
| Kidney | BB64-RCC | A-498 |
| Liver | Hep3B | HepG2 | SK-HEP-1 |
| Lung | NCI-H460 | NCI-H1975 | Calu-6 | A-549 |
| Ovarian | NIH.OVCAR3 | A2780 | SK-OV-3 | PA-1 |
| Prostate | PC3 | LnCap.C4.2 | PC-3 | 22rv1 | MDA-PCa-2b |
| Pancreas | As-PC1 | BxPC3 |
| Stomach/Gastric | AGS | Hs 746T |
Case study with CDX tumor model:
Glioblastoma multiforme (GBM) remains one of the most aggressive and treatment resistant brani tumors. Here, the U-87 MG human glioblastoma cell live was used subcutaneously in rats. The antitumor efficacy of two therapeutic agents (Sorafenib and Temozolomide (TMZ)) was individually evaluated using tumor volume reduction as the primary endpoint.
We observed different profiles of response: exponential tumor growth in the negative control animals after about 30 days, delayed tumor growth with Sorafenib and prevented tumor growth with Temozolomide (TMZ) (SOC for this pathology).
Do you need CDX models for your research programs?
