Patient-Derived Xenograft (PDX) models for in vivo pharmacology studies
Patient derived xenografts (PDX) are models developed for cancer where the tissue or cells are implanted into an immunodeficient or humanized mouse and come from a patient’s tumor. In translational services, PDX models allow to create a more human environment in which we can study cancer progress, its growth and the efficacy of new therapies.
With the support of a CRO (Contract Research Organization) partner, PDX models give you quality data and predictive information of how the new therapy will perform in human, before entering into clinical trials.
PDX models : for what ?
In drug discovery, one of the major factor is the need for cancer models that better represent the native tumor diversity and microenvironment and thus respond to potential cancer drugs in a manner more representative of a human response.
The Patient derived xenografts (PDX) appeared as a reliable option for:
- target validation and candidate selection
- patient populations identification
- biomarkers identification
- modeling drug resistance
Oncodesign Services has a large bank of characterized PDX models
At Oncodesign Services, our customers have access to a comprehensive collection of PDX models (liver, breast, lung, brain, pancreas…) on mouse or rat. If the appropriate model is not available, we can develop a customized.
Our highly collection of Patient-Derived Xenograft (PDX) models is fully integrated with our in vitro experimental platform dedicated to preclinical pharmacology.
We have more than 200 unique PDX models, covering 19 indications. These PDX models have been characterized in regard to:
- Histology
- Conservation of phenotype and genotype
- Gene expression stability
- Gene mutation status
- Response to standard of care (SOC)
Do you need PDX models for your research programs? Contact us!
