Scientific paper - Ressources

Animal models for novel therapies on fibrosis and NASH


Adélaïde Ferment, Jeremy Odillard, Ingrid Jacquet, Benedicte Devin, Laure Levenez, Gaël Krysa, Robin Artus,
Franck Martin, Edwige Nicodeme, Olivier Duchamp, Fabrice Viviani and Samira Benhamouche-Trouillet


We have used a model of NASH-HCC with number of cellular and molecular processes that are reflective of
human NASH and outcomes. Our objectives were to assess:

  • the effect of Elafibranor (Ela) or/and Obeticholic Acid (OCA) on the development of NASH and fibrosis.
  • the effect of Lenvatinib or/and anti-PD-1 on the development of hepatocellular carcinomas (HCC).
  • to assess the sex differences on the pathogenesis and the response to treatments.

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