Antitumour, pharmacokinetics and distribution studies of diflomotecan (bn80915) administered intravenously to nude rats xenografted with human nsc nci-h460 lung tumour cells
Authors: Celma C, Peraire C, Obach R, Bichat F, Guilbaud N, Genne P, Principe P
Ipsen Pharma; Oncodesign; Beaufour Ipsen
Homocamptothecins (HCPTs) are novel anticancer drugs issued from research at Beaufour Ipsen, HCPTs inhibit topoisomerase I (Topo I): in contrast with camptothecins they possess a 7-membered-beta-hydroxylactone ring that displays reduced electrophilicity leading to a considerable stabilization of the active, closed lactone form of the drug…