Validation of Tumor bearing Nude rat as a Model to study Anticancer Druf Pharmacokinetic/ Pharmacodynamic (PK/PD) Relationships
Authors: F Bichat, O Duchamp, N Hoffmann, A Bataille, J Eon, V Bari, N Narboux, N Guilbaud, P Genne.
Oncodesign
Abstract: A key issue in the clinical development of anticancer drugs is to have as much reliable information from relevant in vivo models.
The Nude rat was selected as an appropriate model for human tumor grafting, assessment of delicate surgery, various administration routes of compounds, and repeated sampling.