Syngeneic models

 Syngeneic Models for Drug-Host Immune System Interactions Study

Treatments targeting immune cells such as immune checkpoint modulators, bispecific antibodies or adoptive T cell transfer have now demonstrated their clinical efficacy and some of these therapies have already been approved. However, preclinical development of these therapies requires models adapted to each target and class of therapeutics. To address these needs, Oncodesign Services provides the option to use syngeneic mouse models.

Syngeneic model systems remain one of the best options to analyze physiologically relevant interactions between tumor and immune cells. Indeed, in syngeneic models, animals are grafted with tumor cells from an animal of the same lineage. The main advantage of these models is the use of immunocompetent mice, thus allowing the study of the complex relationships between cancer and the immune system and the evaluation of immunomodulatory therapies.

Oncodesign Services provides a large bank of syngeneic tumor models, including breast cancer, melanoma, bladder cancer, etc .

Examples of syngeneic mouse tumor models available at Oncodesign Services

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Case study: MC38 colon tumor model

Subcutaneous MC38 model -immunotherapy

Syngeneic mice were subcutaneously injected with MC38 murine tumor fragments on Day 0. The mice were randomized based on their tumor volumes on Day 11 and treated intraperitoneally with 10mg/kg/inj of mAb against CTLA-4 (clone9H10, TWx2), PD-1 (cloneRMP1-14, TWx2), PD-L1 (clone10F.9G2, TWx2) or left untreated.

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