In vitro assays
In vitro assays to support drug development
Our in vitro assays drive drug discovery from target identification to preclinical model selection, bridging the gap between lab testing and in vivo evaluation. We’re dedicated to selecting the best lead compounds and advancing them through optimal preclinical protocols.
In vitro assays services to support your drug discovery and preclinical development
At Oncodesign Services, we’re pioneers in scientific innovation, enhancing drug discovery through cutting-edge in vitro assays. We understand that high-quality in vitro data is vital for informed decisions throughout the drug development process.
Located across our two facilities in Dijon and Paris, our in vitro department comprises a team of 35 professionals, including 12 PhDs. Our state-of-the-art laboratories are equipped to handle BSL2 and BSL3 work, providing a range of comprehensive tests, including:
- Biochemistry
- Radioisotope licensed – labeling, quantification
- Molecular biology – cDNA construct design
- CRISPR-Cas 9 licensed
- Cell engineering
- Cell-based assay
- 2D and 3D cell culture
- High content screening capacity
- Digital PCR / Quantitative PCR
- Immunology assay
- Flow cytometry
- Virology (including assay using wild type Covid19 strain)
- Microbiology
In vitro assays readouts
Biochemical and cell based functional assays (including the use of radioisotopes)
Target identification – deconvolution – target validation
Metabolic – proliferation assays
Mechanistic assays: apoptosis, cell cycle, migration, invasion…
Clonogenic assays
Radiotherapeutic assays
Ex-vivo assays
In vitro Platform: cell-assay capabilities and experience with multiple biological samples.
In vitro department offers more than 300 cell lines covering 90% of human cancers as well as PDX derived sample (organoid).
Our in vitro platform offers :
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Molecular Biology
- QPCR-Digital PCR
- Knockdown/Knockout (siRNA/Oligo/CRISPR)
- Overexpression
- Transient and stable transfection
- Cell signaling reporter assay
- Adenovirus – Lentivirus production
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Cell Biology
- High content imaging – immunofluorescence
- Cell signaling – target engagement assay
- Real time celle analysis : migration, invasion, proliferation, sinalisation
- Hypoxia / Hyperoxia
- 3D cell culture: spheroid/PDX organoid
- Flow cytometry
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Biochemistry/enzymology
- Enzymatic assay setup/design
- Assay automation
- Radioisotope labelling
- Binding analysis
- Elisa/MSD/AlphaLISA/HTRF setup and design
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Cell assay
- Phenotypic assay
- Reporter gene and assay design
- Mitobiogenesis – Mitochondrial potential
- Fatty acid oxidation assay
- …
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Robotic MTS (up to 30k cpds)
- Enzymatic assay
- Phenotypic cell based assay
In combination with our medicinal chemists, in vivo pharmacologists, and DMPK scientists, our integrated teams can accelerate your research program by seamlessly integrating compound flow and knowledge.
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